Thiophenol → HCID 57788015, compound

Participants

Reaction Steps

(RS)-S-(4-{[4-(Isopropylamino)-6-methoxyquinazolin-7-yl]oxy}butyl)-S-methyl-N-[(4-nitrophenyl)sulphonyl]sulphoximide (267 mg, 0.48 mmol) is dissolved in acetonitrile (7 ml), treated with caesium carbonate (266 mg, 0.82 mmol) and thiophenol (86 mg, 0.77 mmol) and stirred at room temperature for 20 hours. The reaction batch is diluted with water and methylene chloride. The organic phase is separated off and dried over sodium sulphate. The desired product is obtained after removal of the solvent and preparative HPLC in 51% yield (126 mg).

Provenance & Evidence