Sodium Hydroxide → HCID 57787952, compound

Participants

Reaction Conditions

Reaction Steps

6-Bromo-N-isopropyl-7-{[5-(methylsulphanyl)pyridin-3-yl]methoxy}quinazolin-4-amine (430 mg, 1.03 mmol) is presented as an initial charge in 20 mL of chloroform and at 0° C. and at 0° C. admixed with meta-chloroperbenzoic acid (260 mg, 1.13 mmol). The batch is subsequently stirred at 0° C. for 45 minutes. The batch is introduced into 2N aqueous sodium hydroxide solution. The mixture is extracted with dichloro-methane, the organic phase is dried over sodium sulphate and the solvent is concentrated. Chromatography (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 74% yield (330 mg).

Provenance & Evidence