Sulfuric Acid → HCID 58088339, compound

Participants

Reaction Steps

A solution of 1-{[3,4-bis(methyloxy)phenyl]methyl}-3-methyl-4-[4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione (P3, 100 mg), anisole (107 μL), TFA (4 mL) and H2SO4 (catalytic amount) was heated at 90° C. overnight. The solution was then concentrated in vacuo, dichloromethane was added and the organic phase was washed with NaHCO3 (aqueous saturated solution), dried on sodium sulphate and evaporated in vacuo. The crude was purified by flash chromatography eluting with cyclohexane/ethyl acetate 8/2 to give the title compound (50 mg).

Provenance & Evidence