反应详情

温度

50 °C

To 4-isopropylthiazol-2-amine (1.04 g, 7.31 mmol) in acetonitrile (30 mL) was added 1,1-thiocarbonyldiimidazole (1.7 g, 9.5 mmol). The reaction was stirred at 50° C. for 18 hours. The reaction was cooled to room temperature and the precipitate was filtered and washed with acetonitrile (2×50 mL). The yellow powder was dried in a vacuum oven (40° C.) for 2 hours. The product, N-(4-isopropylthiazol-2-yl)-1H-imidazole-1-carbothioamide (1.02 g, 4.04 mmol, 55.3% yield), was taken directly to the next step without any further purification.

1. temperatureThe reaction was cooled to room temperature
2. filtrationthe precipitate was filtered
3. washwashed with acetonitrile (2×50 mL)
4. customThe yellow powder was dried in a vacuum oven (40° C.) for 2 hours