HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 250014Generated: October 30, 2026
1,1'-Thiocarbonyldiimidazole → N-(6-(difluoromethoxy)benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide
https://huagongshe.com/reaction/250014
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | 6-(Difluoromethoxy)-1,3-benzothiazol-2-amine | HCID 19585898 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(6-(difluoromethoxy)benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide | HCID 58088254 | 66.5% |
Reaction Steps
To 6-(difluoromethoxy)benzo[d]thiazol-2-amine (0.5 g, 2.3 mmol) in acetonitrile (15 mL) was added 1,1′-thiocarbonyldiimidazole (0.49 g, 2.8 mmol). The reaction was stirred at 70° C. overnight. The reaction was cooled to room temperature and the precipitate was filtered to yield N-(6-(difluoromethoxy)benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide (500 mg, 1.53 mmol, 66.3% yield) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07863291B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-a4e910216bcd4b75b1ffbe90d99bf848 |
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| Source note | uspto-grants-2011_01 |
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