2-Amino-3-Hydroxypyridine → (1,3)Oxazolo(4,5-b)pyridin-2-amine

Participants

Reaction Steps

An oven dried round bottom flask was charged with di(1H-imidazol-1-yl)methanimine (500 mg, 3.10 mmol), 2-aminopyridin-3-ol (171 mg, 1.551 mmol) and anhydrous THF (20 ml) at room temperature. The resulting suspension was refluxed under N2 for 1 hr. LC/MS indicated complete consumption of starting material. The solvent was removed in vacuo and the residue was used in the next step without further purification. MS(LC/MS) R.T.=0.235; [M+H]+=136.09.

Provenance & Evidence