4-Hydroxybenzaldehyde → 4-[2-Bromo-2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 0.67 g (0.0055 mol) p-hydroxy benzaldehyde and 0.237 g (0.0098 mol) sodium hydride in 10 mL DMF, 1 g (0.0034 mol) 2-bromo-[5-ethyl-2-pyridyl]-ethyl bromide dissolved in 10 mL of Do was added at 10-15° C. Reaction mixture was stirred for 1 hr at 25-30° C. and further warmed at 75-80° C. for 24 br. After subsequent work-up crude product was obtained which on purification gave titled compound, Yield of the product was 0.068 g (6%). The product obtained was characterized by satisfactory mass.

Provenance & Evidence