HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-[2-Bromo-2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 4-[2-(5-Ethyl-2-pyridinyl)-2-hydroxyethoxy]benzaldehyde | HCID 11550787 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[2-Bromo-2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde | HCID 71379248 | 89.8% |
Reaction Steps
2.93 g (0.01 mol) PBr3 was added to a solution of 5 g (0.018 mol) 4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde dissolved in 50 mL chloroform at 55-60° C. Reaction mixture was refluxed for 1 hr. Progress of the reaction was monitored by TLC and after completion of reaction, subsequent work-up in alkaline water furnished 3 g (50%) of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863300B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-67993b69dcf0498ea359d6585e2b5127 |
| Source note | uspto-grants-2011_01 |