Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 73505385 | HCID 73505385 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86625169 | HCID 86625169 | — |
Reaction Steps
To a stirred solution of 0.65 g (0.0018 mol) 4-[2-(5-ethyl-pyridin-2-yl)-2-mesyl-ethoxy]-benzaldehyde dissolved in 10 mL toluene was added 0.211 g (0.0018 mol) thiazolidin-2,4-dione followed by addition of 0.161 g (0.03 mol) acetic acid and 0.228 g (0.03 mol) piperidine. Reaction mixture was refluxed at 120-130° C. for 4 hr. After completion of reaction on TLC, subsequent work-up gave the titled product. Yield of the product was 0.24 g (29%). The product obtained was identical to the product obtained in example 69.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07863300B2 |
|---|
| Source dataset | uspto-grants-2011_01 |
|---|
| ORD ID | ord-a9185dbb7b424a4f9b323e0646b39482 |
|---|
| Source note | uspto-grants-2011_01 |
|---|
