4-Pyridinecarboxaldehyde → HCID 50885249, compound

Participants

Reaction Steps

Pyridine-4-carboxaldehyde (2.04 g) was mixed with Meldrum's acid (2,2-Dimethyl-[1,3]dioxane-4,6-dione, 2.7 g) and proline (0.20 g) in acetonitrile (40 ml) with stirring under a nitrogen atmosphere. Almost immediately product began to precipitate. The mixture was stirred overnight, filtered and washed with ether, affording 3.7 g of 2,2-dimethyl-5-pyridin-4-ylmethylene-[1,3]dioxane-4,6-dione which was used with no further purification in the next step.

Provenance & Evidence