Potassium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

HRID 25022Notes

Reaction equation

HRID 25022 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[K+:25]>C(O)C>[K+:25].[CH3:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([O-:17])=[O:16])[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 9926783HCID 9926783, compound

Product 1

HCID 208123284-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D, 6.0 g, 19.4 mmol) was dissolved in abs ethanol (20 ml) by warming gently followed by addition of KOH (1.21 g) at 0° C. temperature. The reaction mixture was stirred for one hour, concentrated in vaccuo and lyophilized to give the title compound as white solid.

Workup

  1. temperatureby warming gently
  2. concentrationconcentrated in vaccuo

Sources & evidence

ORD record
ord-fe0df4471ba04ce0b6212d5381bcc379
Source dataset
uspto-grants-2005_02
Patent number
US06858602B2

Reaction notes

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