methyl 6-bromo-1H-indole-2-carboxylate → Methyl 6-bromo-1-methyl-1H-indole-2-carboxylate

HRID 250233Notes

Reaction equation

HRID 250233 reaction equation
COC([C:5]1[C:13]2[C:8](=[CH:9][C:10]([Br:14])=[CH:11][CH:12]=2)[N:7]([CH3:15])[CH:6]=1)=O.[CH3:16][O:17][C:18](C1NC2C(C=1)=CC=C(Br)C=2)=[O:19]>>[CH3:16][O:17][C:18]([C:6]1[N:7]([CH3:15])[C:8]2[C:13]([CH:5]=1)=[CH:12][CH:11]=[C:10]([Br:14])[CH:9]=2)=[O:19]

Participants

3

Reactant 2

HCID 754141methyl 6-bromo-1H-indole-2-carboxylateHCID 57443279Methyl 6-bromo-1-methyl-1H-indole-3-carboxylate

Product 1

HCID 4777911Methyl 6-bromo-1-methyl-1H-indole-2-carboxylate

Procedure

The title compound is prepared essentially as described in the preparation of 6-bromo-1-methyl-1H-indole-3-carboxylic acid methyl ester utilizing 6-bromo-1H-indole-2-carboxylic acid methyl ester, ES/MS m/e 270.0 (M+2).

Sources & evidence

ORD record
ord-75ad529d079949c6961423e0739f8c78
Source dataset
uspto-grants-2011_01
Patent number
US07863302B2

Reaction notes

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