1-Benzothiophene-6-carboxylic acid → 2-Boronobenzo[b]thiophene-6-carboxylic acid

HRID 250242Notes

Reaction equation

HRID 250242 reaction equation
C([C:4]1[C:12]2[CH:11]=[C:10]([B:13]([OH:15])[OH:14])[S:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)(O)=O.S1C=CC2C=CC([C:25]([OH:27])=[O:26])=CC1=2>>[C:25]([C:6]1[CH:5]=[CH:4][C:12]2[CH:11]=[C:10]([B:13]([OH:14])[OH:15])[S:9][C:8]=2[CH:7]=1)([OH:27])=[O:26]

Participants

3

Reactant 2

HCID 6012811-Benzothiophene-6-carboxylic acidHCID 67272237(4-Carboxybenzo[b]thiophen-2-yl)boronic acid

Product 1

HCID 672718042-Boronobenzo[b]thiophene-6-carboxylic acidYield 86%

Procedure

The title compound (120 g, 86%) is prepared essentially as described in the preparation of 4-carboxy-benzo[b]thiophen-2-boronic acid utilizing benzo[b]thiophene-6-carboxylic acid, ES/MS m/e 221 M−1).

Sources & evidence

ORD record
ord-e76d52a59dbd4eb1b973a8cea3fffa20
Source dataset
uspto-grants-2011_01
Patent number
US07863302B2

Reaction notes

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