Ethyl Acetoacetate → Ethyl 3-(cyclopropylamino)but-2-enoate

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl acetoacetate (5.00 mL, 39.3 mmol) and cyclopropylamine (3.27 mL, 47.1 mmol) is stirred at 40° C. for 3 h. The mixture is concentrated under high vacuum overnight to give the title compound (6.23 g, 94%) of the as an oil, which is used without further purification in the next reaction.

Provenance & Evidence