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A −78° C. solution of 6-methoxy-benzofuran-3-carboxylic acid ethyl ester (1.50 g, 6.81 mmol) in dichloromethane (20 mL) is treated with boron tribromide (20 mL) dropwise. The mixture is stirred at 0° C. for 60 minutes. The reaction is quenched by adding MeOH (10 mL) dropwise over 10 minutes. The mixture is concentrated. The residue is purified via flash chromatography eluting with 25% EtOAc/hexanes to provide the title compound (0.95 g, 68%). ES/MS m/e 207.0 (M+1), 205.0 (M−1).

1. customThe reaction is quenched
2. additionby adding MeOH (10 mL) dropwise over 10 minutes
3. concentrationThe mixture is concentrated
4. customThe residue is purified via flash chromatography
5. washeluting with 25% EtOAc/hexanes