Potassium Carbonate → HCID 58088345, compound

Participants

Reaction Steps

To a solution of 4-bromomethyl-5-cyclopropyl-3-(2-fluoro-6-trifluoromethyl-phenyl)-isoxazole (0.083 g, 0.256 mmol) and 2-(4-Hydroxy-2-methyl-phenyl)-4-methyl-thiazole-5-carboxylic acid methyl ester (0.067 g, 0.256 mmol) in 1 mL of DMF is added potassium carbonate (0.035 g, 0.256). The reaction is stirred for 60 hours. The reaction is partitioned between ethyl acetate and water. The layers are separated and the organic layer is washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue is chromatographed using a gradient of 5% ethyl acetate in hexanes to 40% ethyl acetate in hexanes to yield the title compound (0.027 g, 18%). ES/MS m/e 547.0 (M+1).

Provenance & Evidence