L-Alanine → HCID 57473363, compound

HRID 250324Notes

Reaction equation

HRID 250324 reaction equation
C(O[C:6]([C:8]1[N:9]=[CH:10][C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][C:14]([O:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1)=[CH:13][CH:12]=2)=[O:7])CCC.[NH2:27][C@H:28]([C:30]([OH:32])=[O:31])[CH3:29]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[CH:10]=[N:9][C:8]([C:6]([NH:27][C@@H:28]([CH3:29])[C:30]([OH:32])=[O:31])=[O:7])=[C:17]3[OH:18])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 5950L-AlanineHCID 66713079HCID 66713079, compound

Product 1

HCID 57473363HCID 57473363, compound

Procedure

Prepared in analogy to Example A-50 by reacting 6-(4-Chloro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (compound of Example A-60 b) with L-alanine in a microwave reactor for 25 min at 130° C. MS-(−)-ion: M−1=385.1

Workup

  1. customfor 25 min
  2. customat 130° C

Sources & evidence

ORD record
ord-cdaab851423d44fe8a6780e159890b25
Source dataset
uspto-grants-2011_01
Patent number
US07863292B2

Reaction notes

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