反应详情

To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-2-butenoate (Step E) in abs ethanol at low temp, add aqueous sodium hydroxide, after an hour, concentrate and purify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid).

1. waitafter an hour
2. concentrationconcentrate
3. custompurify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid)