反应详情

A mixture of 4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carboxylic acid butyl ester (0.20 g) and L-alanine (0.75 g) in 0.5 M NaOMe/MeOH (11.3 ml) was heated to reflux for 36 h. After cooling, reaction mixture was concentrated. The residue was suspended in water (50 ml) and extracted with ethyl acetate (50 ml) which was discarded. The aqueous layer was acidified by 2 N HCl aqueous solution. Extracted with ethyl acetate (2×50 ml). Combined organic layers were dried over magnesium sulfate, filtered, and concentrated to give the title compound (0.15 g). MS-(−)-ion: M−1=367.1.

1. temperaturewas heated
2. temperatureto reflux for 36 h
3. temperatureAfter cooling
4. customreaction mixture
5. concentrationwas concentrated
6. extractionextracted with ethyl acetate (50 ml) which
7. extractionExtracted with ethyl acetate (2×50 ml)
8. dry with materialCombined organic layers were dried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated