Methanesulfonyl chloride → N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-(methanesulfonylamino)methyl-N-(2-methoxyphenyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	4-aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide	HCID 19689859	—
Product	N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-(methanesulfonylamino)methyl-N-(2-methoxyphenyl)benzamide	HCID 19689935	57.5%

Reaction Steps

Using 4-aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]-ethyl}-N-(2-methoxyphenyl)benzamide (60 mg, 0.123 mmol) and methanesulfonyl chloride (11 μl, 0.142 mmol), the procedure of Inventive Example 94 was repeated to obtain 40 mg (57.5%) of the title compound in a colorless amorphous form.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05728835
Source dataset	uspto-grants-1998_03
ORD ID	ord-19a9af2199cc4a38989a98f4ca8a5f8d
Source note	uspto-grants-1998_03