反应详情

Iodomethane (1.76 ml) was added to 4-cyanophenyl-thiourea (5.0 g) in acetone (100 ml). The reaction mixture was stirred overnight at RT. The precipitate was filtered off, dried and dissolved in DCM. The organic solution was washed with NH3 (aq.) (excess), dried with potassium carbonate, filtered, and the solvent was evaporated, yielding 4.53 g (84%, white solid) of methyl N′-(4-cyanophenyl)-carbamimidothioate (intermediate 6).

1. filtrationThe precipitate was filtered off
2. customdried
3. dissolutiondissolved in DCM
4. washThe organic solution was washed with NH3 (aq.) (excess)
5. dry with materialdried with potassium carbonate
6. filtrationfiltered
7. customthe solvent was evaporated