反应详情

A mixture of 4-benzyloxy-1-dimethylcarbamoyl-isoquinoline-3-carboxylic acid benzyl ester (308 mg, 0.7 mmol), KOH (325 mg, 5 mmol) and EtOH (10 ml) was stirred at ambient temperature for 18 h before the solvent was evaporated in vacuo. To the residue was added water (25 ml) and the mixture was washed with Et2O (2×25 ml). Then the solution was acidified by addition of aqueous 6N HCl and extracted with EtOAc (2×25 ml). The combined organic phases were dried over MgSO4 and concentrated in vacuo to give the title compound as a yellowish gum (220 mg); MS-(+)-ion: M+1=351.0.

1. customwas evaporated in vacuo
2. additionTo the residue was added water (25 ml)
3. washthe mixture was washed with Et2O (2×25 ml)
4. additionThen the solution was acidified by addition of aqueous 6N HCl
5. extractionextracted with EtOAc (2×25 ml)
6. dry with materialThe combined organic phases were dried over MgSO4
7. concentrationconcentrated in vacuo