反应详情

A mixture of 1-bromo-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (6.48 g, 20 mmol; Example D-28 a), benzyl bromide (3.6 ml, 30 mmol), K2CO3 (12.44 g, 90 mmol) and acetone (300 ml) was refluxed with stirring for 2.5 d. The solvent was then evaporated in vacuo. To the residue was added water (100 ml) and the mixture was extracted with EtOAc (100 ml). The organic phase was dried over MgSO4 and evaporated in vacuo to give the title compound as a yellowish solid; MS-(+)-ion: M+1=414.1.

1. customThe solvent was then evaporated in vacuo
2. additionTo the residue was added water (100 ml)
3. extractionthe mixture was extracted with EtOAc (100 ml)
4. dry with materialThe organic phase was dried over MgSO4
5. customevaporated in vacuo