4-Benzyloxy-1-isobutyl-isoquinoline-3-carboxylic acid butyl ester → 4-Hydroxy-1-isobutyl-isoquinoline-3-carboxylic acid butyl ester

HRID 250492노트

반응식

HRID 250492 반응식
[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:11]2[C:16]([C:17]=1[O:18]CC1C=CC=CC=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]>[Pd].CCOC(C)=O>[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 667132624-Benzyloxy-1-isobutyl-isoquinoline-3-carboxylic acid butyl ester

생성물 1

HCID 667127764-Hydroxy-1-isobutyl-isoquinoline-3-carboxylic acid butyl ester수율 90.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-Benzyloxy-1-isobutyl-isoquinoline-3-carboxylic acid butyl ester (125 mg, 0.32 mmol), Pd/C (50 mg, Aldrich, 10 wt % Pd) and EtOAc (15 ml) were stirred at ambient pressure and temperature under an H2 atmosphere for 24 h. The mixture was then filtered through a pad of celite. Concentration of the filtrate in vacuo yielded the title compound as a yellowish oil (87 mg); MS-(+)-ion M+1=302.2.

후처리

  1. filtrationThe mixture was then filtered through a pad of celite

출처 및 근거

ORD 기록
ord-6028ff85defe4c899cb1f779d6ae3ee5
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863292B2

반응 노트

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