4-Hydroxy-7-phenoxy-1-vinyl-isoquinoline-3-carboxylic acid butyl ester → 1-Ethyl-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester

HRID 250496Notes

Reaction equation

HRID 250496 reaction equation
[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([CH:26]=[CH2:27])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[C:13]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4].C1C=CC(C([C@@H]2OC[C@H](NCC3C=CC(F)=CC=3)C(O)C2)C2C=CC=CC=2)=CC=1>>[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([CH2:26][CH3:27])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[C:13]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 667132814-Hydroxy-7-phenoxy-1-vinyl-isoquinoline-3-carboxylic acid butyl esterHCID 71452722D-153 (FDA NDC: 58264-0164)

Product 1

HCID 667129111-Ethyl-4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester

Procedure

Synthesized from 4-Hydroxy-7-phenoxy-1-vinyl-isoquinoline-3-carboxylic acid butyl ester in analogy to example D-153 b); MS-(+)-ion M+1=366.1.

Sources & evidence

ORD record
ord-03c5a6d088bf4338a328fc5b463f6537
Source dataset
uspto-grants-2011_01
Patent number
US07863292B2

Reaction notes

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