Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-1,2-propanediol → 4-[[4-[(2,6-Dichlorophenyl)methyl]-6-(2,3-dihydroxypropylamino)-1,3,5-triazin-2-yl]amino]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 반응물 | 4-[[4-Chloro-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]benzonitrile | HCID 486423 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[[4-[(2,6-Dichlorophenyl)methyl]-6-(2,3-dihydroxypropylamino)-1,3,5-triazin-2-yl]amino]benzonitrile | HCID 505418 | 98.2% |
반응 단계
A mixture of intermediate (27) (0.00256 mol) and 3-amino-1,2-propanediol (0.00563 mol) in 1,4-dioxane (10 ml) and 1-methyl-pyrrolidinone (2 ml) was stirred at RT for 48 hours under argon. The reaction mixture was concentrated, quenched with DCM/H2O and stirred. The precipitate was filtered off, yielding 1.12 g (86.9%) of (±)-4-[[4-[(2,6-dichlorophenyl)methyl]-6-[(2,3-dihydroxypropyl)amino]-1,3,5-triazin-2-yl]amino]benzonitrile (compound 26).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858609B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-03bc4a0b0eb641639980ecae02ca4a58 |
| 출처 메모 | uspto-grants-2005_02 |