HCID 58086725, compound → HCID 58087284, compound

HRID 250598Notes

Reaction equation

C(NC(N1C2C(=C(CC3C4C(=NC=C(C5C=NC=CC=5)C=4)NC=3)C=CC=2)C=C1)=O)CCC.[CH2:33]([NH:37][C:38]([N:40]1[C:48]2[C:43](=[C:44]([CH:49]([OH:65])[C:50]3[C:58]4[C:53](=[N:54][CH:55]=[C:56]([C:59]5[CH:60]=[N:61][CH:62]=[CH:63][CH:64]=5)[CH:57]=4)[NH:52][CH:51]=3)[CH:45]=[CH:46][CH:47]=2)[CH:42]=[CH:41]1)=[O:39])[CH2:34][CH2:35][CH3:36]>>[CH2:33]([NH:37][C:38]([N:40]1[C:48]2[C:43](=[C:44]([C:49]([C:50]3[C:58]4[C:53](=[N:54][CH:55]=[C:56]([C:59]5[CH:60]=[N:61][CH:62]=[CH:63][CH:64]=5)[CH:57]=4)[NH:52][CH:51]=3)=[O:65])[CH:45]=[CH:46][CH:47]=2)[CH:42]=[CH:41]1)=[O:39])[CH2:34][CH2:35][CH3:36]

Participants

Reactant 2

HCID 58086725HCID 58086725, compound

HCID 58086855HCID 58086855, compound

Product 1

HCID 58087284HCID 58087284, compound

Procedure

The product of Step 2 of Scheme 41 can alternatively be reacted to form the corresponding compounds with methylene linker at the 3 position of the azaindole. For example, 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-indole-1-carboxylic acid butylamide P-1656 was prepared from 4-[Hydroxy-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-indole-1-carboxylic acid butylamide 520 as shown in Scheme 41a.

Sources & evidence

ORD record: ord-812eee8221bb4f09a6e90958e43fc60e
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07863288B2

Reaction notes

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