HCID 70315987, compound → HCID 58086855, compound

HRID 250599Notes

Reaction equation

HRID 250599 reaction equation
[CH2:1]([NH:5][C:6]([N:8]1[C:16]2[C:11](=[C:12]([CH2:17][C:18]3[C:26]4[C:21](=[N:22][CH:23]=[C:24]([C:27]5[CH:28]=[N:29][C:30](OC)=N[CH:32]=5)[CH:25]=4)[NH:20][CH:19]=3)[CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].[CH2:35](NC(N1C2C(=C(CC3C4C(=NC=C(OC)C=4)NC=3)C=CC=2)C=C1)=O)CCC.C(NC(N1C2C(=C(CC3C4C(=NC=C(C5C=CN=CC=5)C=4)NC=3)C=CC=2)C=C1)=O)CCC>>[CH2:1]([NH:5][C:6]([N:8]1[C:16]2[C:11](=[C:12]([CH2:17][C:18]3[C:26]4[C:21](=[N:22][CH:23]=[C:24]([C:27]5[CH:28]=[N:29][CH:30]=[CH:35][CH:32]=5)[CH:25]=4)[NH:20][CH:19]=3)[CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 70315987HCID 70315987, compoundHCID 70319066HCID 70319066, compoundHCID 70319068HCID 70319068, compound

Product 1

HCID 58086855HCID 58086855, compound

Procedure

The corresponding hydroxy-methyl derivative of Scheme 41 Step 2 was reacted following the protocol of Scheme 41a to prepare 4-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-indole-1-carboxylic acid butylamide P-1861, 4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-indole-1-carboxylic acid butylamide P-1876, and 4-(5-Pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-indole-1-carboxylic acid butylamide P-1877, with structures shown below.

Sources & evidence

ORD record
ord-e8c41bc0cc384fe6a49155e24775c92a
Source dataset
uspto-grants-2011_01
Patent number
US07863288B2

Reaction notes

Loading…