反应详情

To a stirred solution of 0.40 g (1.0 mmol) of compound XVIII in 15 ml of chloroform 0.07 ml (1.2 mmol) of methyl isocyanate was added. After 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water and after concentration the obtained solid material was purified by refluxing in ethanol. The desired product was 0.36 g, yield: 88%. Mp.: 200° C.

1. washAfter 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water
2. concentrationafter concentration the obtained solid material
3. customwas purified
4. temperatureby refluxing in ethanol