1-(Bromomethyl)-4-chlorobenzene → 4-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

HRID 250622Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 250622
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[OH:19])[CH:14]=[O:15]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:19][C:18]2[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][C:11]=2[F:10])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 5872503-Fluoro-4-hydroxybenzaldehyde

Produkt 1

HCID 580863304-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

Versuchsvorschrift

Additional aldehydes were prepared using the protocol of Scheme 62, replacing either 4-chlorobenzyl bromide 557 with a suitable alkylating agent, and/or 3-fluoro-4-hydroxy-benzaldehyde 598 with a suitable aldehyde. The following table indicates the alkylating agent (column 1) and the starting aldehyde (column 2) used to afford the aldehyde (column 3) synthesized following this protocol.

Quellen und Nachweise

ORD-Eintrag
ord-d94c0074a2a94119906c11d2f24c64a1
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863288B2

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