HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25063Generated: October 26, 2026
Dimethylformamide → (+/-)-8-Methyl-5-(4-nitrophenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
https://huagongshe.com/reaction/25063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Reactant | (+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137394 | — |
| Solvent | Water | HCID 962 | — |
| Product | (+/-)-8-Methyl-5-(4-nitrophenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137420 | 80% |
Reaction Steps
A mixture of 1.00 g (2.60 mmol) of the starting material I, 2.54 g (12.89 mmol) of bromoacetaldehyde diethyl acetal and 10 ml of dimethylformamide was stirred at 80° C. for 40 min. Then the reaction mixture was diluted with water and the crude product obtained was recrystallized from ethanol to yield 0.85 g (80%) of the title compound. Mp.: 145-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06858605B2 |
|---|
| Source dataset | uspto-grants-2005_02 |
|---|
| ORD ID | ord-d6fbdcbbe9454367a6b64eb88f7e508c |
|---|
| Source note | uspto-grants-2005_02 |
|---|
