Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Pyrrolo(2,3-b)pyridine → N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3,5-difluorobenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 반응물 | Sulfuryl chloride | HCID 24648 | — |
| 반응물 | 3,5-Difluorobenzenesulfonyl chloride | HCID 2774058 | — |
| 반응물 | 5-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 24229213 | — |
| 반응물 | (3-Amino-2,6-difluorophenyl)(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone | HCID 58086044 | — |
| 생성물 | N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3,5-difluorobenzenesulfonamide | HCID 58086516 | — |
반응 단계
Additional compounds were prepared following the protocol of Scheme 67 Step 6, optionally substituting (3-Amino-2,6-difluoro-phenyl)-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone P-1801 with (3-Amino-2,6-difluoro-phenyl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone P-2021 (prepared per Scheme 67 Steps 1-5, substituting 5-chloro-1H-pyrrolo[2,3-b]pyridine 80 with 1H-pyrrolo[2,3-b]pyridine 94 in Step 3) and/or 3,5-difluorobenzenesulfonyl chloride 610 with an appropriate sulfonyl chloride. The following compounds were prepared by this procedure:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863288B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-4dbd065376c34c6fb7d4dd96c791eec5 |
| 출처 메모 | uspto-grants-2011_01 |