HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25069Generated: October 26, 2026
Dimethylformamide → (+/-)-7-(4,5-Dihydro-5-methyl-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
https://huagongshe.com/reaction/25069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ethyl 2-bromopropionate | HCID 79040 | — |
| Reactant | (+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137394 | — |
| Solvent | Water | HCID 962 | — |
| Product | (+/-)-7-(4,5-Dihydro-5-methyl-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137432 | 95% |
Reaction Steps
A mixture of 1.00 g (2.60 mmol) of the starting material I, 0.94 g (5.19 mmol) of ethyl 2-bromopropionate and 10 ml of dimethylformamide was stirred at 80-90° C. for 2 h. After diluting with water the obtained crude product was purified by refluxing in 15 ml of ethanol to yield 1.08 g (95%) of the title compound; Mp.: 213-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06858605B2 |
|---|
| Source dataset | uspto-grants-2005_02 |
|---|
| ORD ID | ord-7485b3d401664163aaf0601da93eec85 |
|---|
| Source note | uspto-grants-2005_02 |
|---|
