Stannous Chloride → HCID 178507461, compound

Participants

Reaction Conditions

Reaction Steps

Add tin(II) chloride (0.11 g, 0.6 mmol) to a solution of 2-(2,6-difluorophenyl)-4-phenyl-5-(3-(benzyl)amino-4-nitrophenyl)imidazole (0.09 g, 0.2 mmol) in 10 mL acetic acid. Bubble nitrogen through the solution for 15 minutes and then heat at 90° C. for 1 hour under a nitrogen atmosphere. Cool the reaction mixture to room temperature, dilute with ethyl acetate, and then wash sequentially with 3:1 ammonium hydroxide:saturated aqueous ammonium chloride, saturated aqueous sodium chloride, and water. Dry the organic phase over magnesium sulfate and concentrate under reduced pressure. Subject the residue to silica gel chromatography, eluting with 5:1 dichloromethane:acetonitrile to provide the title compound (0.05 g, 59%).

Provenance & Evidence