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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 250746Generated: November 2, 2026

1-benzyl-2-methyl bromo-5-(2,4-difluorophenyl)-1H-imidazole → 1-Benzyl-2-methyl-4-(3-(N-[3-methylbut-2-yl]-N-[cyano]amino)-4-nitrophenyl)-5-(2,4-difluorophenyl)-1H-imidazole

https://huagongshe.com/reaction/250746

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-benzyl-2-methyl bromo-5-(2,4-difluorophenyl)-1H-imidazoleHCID 17981672—
ReactantN-[cyano]N-[3-methylbut-2-yl]2-nitro-5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)anilineHCID 86623269—
Product1-Benzyl-2-methyl-4-(3-(N-[3-methylbut-2-yl]-N-[cyano]amino)-4-nitrophenyl)-5-(2,4-difluorophenyl)-1H-imidazoleHCID 86623268—

Reaction Steps

Beginning with 1-benzyl-2-methyl-4-bromo-5-(2,4-difluorophenyl)-1H-imidazole and N-[cyano]N-[3-methylbut-2-yl]2-nitro-5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)aniline, the title compound is prepared essentially as described in Preparation 35.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07863310B2
Source datasetuspto-grants-2011_01
ORD IDord-656ab5f7dc28457d85f02e98240b5fe8
Source noteuspto-grants-2011_01