HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 250748Generated: October 25, 2026
Water → (5-Chloro-2-nitrophenyl)-(1-(R)-methyl-2,2-dimethylpropyl)amine
https://huagongshe.com/reaction/250748
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-2-fluoro-1-nitrobenzene | HCID 69691 | — |
| Reactant | (R)-3,3-Dimethyl-2-aminobutane | HCID 5324845 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (5-Chloro-2-nitrophenyl)-(1-(R)-methyl-2,2-dimethylpropyl)amine | HCID 66869060 | 100.5% |
Reaction Steps
Add 2-(R)-amino-3,3-dimethylbutane (20 mL, 0.148 mol), potassium carbonate (14.3 g, 0.104 mol) and water (50 mL) to a solution of 4-chloro-2-fluoronitrobenzene (13.3 g, 0.076 mol) in THF (450 mL) and stir at 75° C. for 3 h Cool to ambient temperature. Concentrate to ½ volume, dilute with ethyl acetate and wash with 1N HCl (4×100 mL), water, saturated sodium bicarbonate, saturated sodium chloride, dry with magnesium sulfate and concentrate to give the title compound as an orange solid (19.6 g, quant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07863310B2 |
|---|
| Source dataset | uspto-grants-2011_01 |
|---|
| ORD ID | ord-9f13736c3cc0452799f7c738cd081826 |
|---|
| Source note | uspto-grants-2011_01 |
|---|
