Trityl chloride → HCID 22031021, compound

Participants

Reaction Conditions

Reaction Steps

Add triphenylmethylchloride (4.78 g, 17.2 mmol)) and dimethylaminopyridine (0.350 g, 2.86 mmol) to a stirred solution of 3-(2,4-difluorophenyl)-1H-pyrazole (2.58 g, 14.33 mmol) in dry pyridine (30 mL). Stir at 80° C. for about 18 hours. Cool to RT, concentrate and purify (silica gel chromatography, eluting with a gradient of hexane dichloromethane 25:75 to 0:100) to give the desired compound (43%).

Provenance & Evidence