反应详情

Stir a mixture of 2-bromo-4′-fluoroacetophenone (100 g, 460 mmol) and 2,2-dimethylpropionamide (93.06 g, 20 mmol) in 1,4-dioxane (600 mL) at reflux for 2 days. Filter the reaction mixture and concentrate the filtrate under reduced pressure. Subject the residue to silica gel chromatography, eluting with 60:1 hexane:ethyl acetate to provide 55 g (55%) of the desired compound.

1. temperatureat reflux for 2 days
2. filtrationFilter the reaction mixture
3. concentrationconcentrate the filtrate under reduced pressure
4. washeluting with 60:1 hexane