Cyanogen Bromide → HCID 66869562, compound

Participants

Reaction Steps

Add cyanogen bromide (101 mg, 0.96 mmol) to a solution of 1-(cyclohexyl)-4-phenyl-5-(3-(isobutylamino)-4-aminophenyl)-1H-imidazole (250 mg, 0.64 mmol) in 6 mL ethanol. Stir over night at room temperature. Add saturated aqueous sodium carbonate and extract well with 9:1 ethyl acetate:methanol. Combine the organic phases, dry over magnesium sulfate, and concentrate under reduced pressure. Subject the residue to silica gel chromatography, eluting with a gradient of 5-8% methanol in dichloromethane to provide the title compound (52%).

Provenance & Evidence