Trimethyl orthoformate → HCID 66869159, compound

Participants

Reaction Steps

Heat a mixture of 1-(cyclohexyl)-4-phenyl-5-(3-(isobutylamino)-4-aminophenyl)-1H-imidazole (83 mg, 0.21 mmol) and 3 mL trimethyl orthoformate at 120° C. for 6 hours. Cool to room temperature and concentrate under reduced pressure. Subject the residue to silica gel chromatography, eluting with 3:1 ethyl acetate:hexanes to provide the title compound (73%).

Provenance & Evidence