Ethyl orthoformate → HCID 66869142, compound

Participants

Reaction Steps

Heat a mixture of 1-(cyclohexyl)-4-phenyl-5-(3-(isobutylamino)-4-aminophenyl)-1H-imidazole (103 mg, 0.26 mmol) and 3 mL triethylorthoformate at 120° C. for 3 hours. Cool to room temperature and concentrate under reduced pressure. Subject the residue to silica gel chromatography, eluting with 2:1 ethyl acetate:hexanes to provide the title compound (45%).

Provenance & Evidence