HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-Isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-Isobutyl-2-amino-6-formylbenzimidazole | HCID 86067152 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole | HCID 66868860 | 99.7% |
Reaction Steps
Add methylamine (3.0 mL, 6 mmol, 2M in tetrahydrofuran) to a solution 1-isobutyl-2-amino-6-formylbenzimidazole (475 mg, 2.19 mmol) in dimethylformamide (5 mL). Stir at room temperature for 18 hours. Concentrate under reduced pressure to provide the title compound (503 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863310B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-4e13cb2630424527b0ce4bde33ce3931 |
| Source note | uspto-grants-2011_01 |