HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methanesulfonic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | a-Tosyl-(4-fluorobenzyl) isocyanide | HCID 10827289 | — |
| Reactant | 1-Isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole | HCID 66868860 | — |
| Reactant | 1-(isobutyl)-2-amino-6-(1-methyl-4 (4-fluorophenyl)-1H-imidazol-5-yl)-1H-benzimidazole | HCID 66869065 | — |
| Product | Methanesulfonic Acid | HCID 6395 | — |
| Product | 1-(Isobutyl)-2-amino-6-(1-methyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-1H-benzimidazole methanesulfonate | HCID 86623270 | — |
Reaction Steps
Beginning with 1-isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole (142 mg, 0.52 mmol), α-(p-toluenesulfonyl)-4-fluorobenzylisocyanide (302 mg, 1.05 mmol), methanol (2.5 ml), and methylamine (1.3 ml, 2M in tetrahydrofuran), 1-(isobutyl)-2-amino-6-(1-methyl-4 (4-fluorophenyl)-1H-imidazol-5-yl)-1H-benzimidazole may be prepared essentially as described in EXAMPLE 72. Treatment with 1 equivalent of methanesulfonic acid provides the title compound (114 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863310B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-08c9dd81fecc4ba6a5fb335f5e4dde4d |
| Source note | uspto-grants-2011_01 |