Cesium carbonate → HCID 66868822, compound

Participants

Reaction Steps

Add cesium carbonate (408 mg, 1.25 mmol) and chloromethyl ethyl ether (0.057 ml, 0.62 mmol) to a solution of 1-isobutyl-2-amino-6-(4-phenyl-2H-[1,2,3]triazol-5-yl)-1H-benzimidazole (208 mg, 0.62 mmol) in DMF (5 tri). Stir for 2 hours at RT, add aqueous ammonium chloride solution (20 ml) and extract with diethyl ether (20 ml). Dry over magnesium sulfate, concentrate and purify (radial silica gel chromatography, eluting with hexane:ethyl acetate 1:1) to provide the title compound as a white solid (32 mg, 13%).

Provenance & Evidence