4-Bromo-5-methyl-3-phenylisoxazole → 1-Isopropylsulfonyl-2-amino-6-(3-phenyl-5-methylisoxazol-4-yl)benzimidazole

HRID 250777Notes

Reaction equation

HRID 250777 reaction equation
[C:1]1([C:7]2[C:11](Br)=[C:10]([CH3:13])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:14]([S:17]([N:20]1[C:24]2[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][C:23]=2[N:22]=[C:21]1[NH2:32])(=[O:19])=[O:18])([CH3:16])[CH3:15]>>[CH:14]([S:17]([N:20]1[C:24]2[CH:25]=[C:26]([C:11]3[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)=[N:8][O:9][C:10]=3[CH3:13])[CH:27]=[CH:28][C:23]=2[N:22]=[C:21]1[NH2:32])(=[O:18])=[O:19])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 114363324-Bromo-5-methyl-3-phenylisoxazoleHCID 17981723HCID 17981723, compound

Product 1

HCID 668693871-Isopropylsulfonyl-2-amino-6-(3-phenyl-5-methylisoxazol-4-yl)benzimidazole

Procedure

Beginning with 3-phenyl-4-bromo-5-methylisoxazole and 1-isopropylsulfonyl-2-aminobenzimidazole-6-boronic acid, the title compound may be prepared essentially as described in EXAMPLE 59.

Sources & evidence

ORD record
ord-831659b2fee04d66b9f77b6a60d549da
Source dataset
uspto-grants-2011_01
Patent number
US07863310B2

Reaction notes

Loading…