methyl(E)-3-(2-methoxy-3'-methylaminobiphenyl-4-yl)acrylate → Methyl 3-(2-methoxy-3'-methylaminobiphenyl-4-yl)propanoate

Participants

Reaction Steps

100 mg (18% by mass) of 10% palladium-on-charcoal are added to a solution of 560 mg (1.88 mmol, 1 eq) of methyl (E)-3-(2-methoxy-3′-methylaminobiphenyl-4-yl)acrylate in 10 ml of methanol. The reaction mixture is stirred at room temperature under a hydrogen atmosphere for 4 hours. The reaction medium is filtered through Celite and then evaporated to dryness. 495 mg of methyl 3-(2-methoxy-3′-methylaminobiphenyl-4-yl)propanoate are obtained in oil form. Yield=88%

Provenance & Evidence