Sodium Hydroxide → HCID 11605749, compound

Participants

Reaction Steps

In a manner similar to that of Example (19g), by reaction of 200 mg (5.0 mmol, 12.8 eq) of sodium hydroxide and 200 mg (0.39 mmol, 1 eq) of methyl (E)-3-[2-benzyloxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]acrylate in 6 ml of a tetrahydrofuran/methanol mixture (8/2), and after crystallization from pentane, 125 mg of (E)-3-[2-benzyloxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]acrylic acid are obtained in the form of a white powder (m.p.=115-116° C.). Yield=64%

Provenance & Evidence