Butyl iodide → HCID 67273737, compound

Participants

Reaction Steps

In a manner similar to that of Example (25a), by reaction of 114 μL (1.0 mmol, 1.5 eq) of 1-iodobutane and 285 mg (0.67 mmol, 1 eq) of methyl 3-[3′-(3-heptyl-1-methylureido)-2-hydroxybiphenyl-4-yl]propanoate (prepared in Example 15f) in 6 ml of methyl ethyl ketone in the presence of 200 mg of potassium carbonate, methyl 3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]propanoate is obtained in oil form and is used in the following reaction without further purification.

Provenance & Evidence