Sodium Hydroxide → HCID 11531614, compound

HRID 250880Notes

Reaction equation

HRID 250880 reaction equation
[OH-].[Na+].[CH2:3]([N:5]([C:16]1[CH:17]=[C:18]([C:22]2[CH:27]=[CH:26][C:25](/[CH:28]=[CH:29]/[C:30]([O:32]C)=[O:31])=[CH:24][CH:23]=2)[CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[O:7])[CH3:4]>O1CCCC1.CO>[CH2:3]([N:5]([C:16]1[CH:17]=[C:18]([C:22]2[CH:27]=[CH:26][C:25](/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31])=[CH:24][CH:23]=2)[CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[O:7])[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67272939HCID 67272939, compound

Product 1

HCID 11531614HCID 11531614, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

In a manner similar to that of Example (19g), by reaction of 400 mg (10 mmol, 5.5 eq) of sodium hydroxide and 775 mg (1.83 mmol, 1 eq) of methyl (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylate in 15 ml of a tetrahydrofuran/methanol mixture (8/2), and after crystallization from dichloromethane/heptane, 580 mg of (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylic acid are obtained in the form of a white powder (m.p.=116° C.). Yield=77%

Workup

  1. customafter crystallization from dichloromethane/heptane, 580 mg of (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylic acid

Sources & evidence

ORD record
ord-1c5c451e07004834bcb412fc7d22cc64
Source dataset
uspto-grants-2011_01
Patent number
US07863332B2

Reaction notes

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