反应详情

In a manner similar to that of Example (19g), by reaction of 400 mg (10 mmol, 5.5 eq) of sodium hydroxide and 775 mg (1.83 mmol, 1 eq) of methyl (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylate in 15 ml of a tetrahydrofuran/methanol mixture (8/2), and after crystallization from dichloromethane/heptane, 580 mg of (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylic acid are obtained in the form of a white powder (m.p.=116° C.). Yield=77%

1. customafter crystallization from dichloromethane/heptane, 580 mg of (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylic acid