Sodium Hydroxide → HCID 11604208, compound

HRID 250883Notes

Reaction equation

HRID 250883 reaction equation
[OH-].[Na+].[CH2:3]([N:6]([C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]([O:33]C)=[O:32])=[CH:25][CH:24]=2)[CH:20]=[CH:21][CH:22]=1)[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:8])[CH2:4][CH3:5]>O1CCCC1.CO>[CH2:3]([N:6]([C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32])=[CH:25][CH:24]=2)[CH:20]=[CH:21][CH:22]=1)[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:8])[CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67272966HCID 67272966, compound

Product 1

HCID 11604208HCID 11604208, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

In a manner similar to that of Example (19g), by reaction of 400 mg (10 mmol, 6.4 eq) of sodium hydroxide and 680 mg (1.55 mmol, 1 eq) of methyl (E)-3-[3′-(1-propyl-3-heptylureido)biphenyl-4-yl]acrylate in 15 ml of a tetrahydrofuran/methanol mixture (8/2), and after crystallization from dichloromethane/heptane, 560 mg of (E)-3-[3′-(1-propyl-3-heptylureido)biphenyl-4-yl]acrylic acid are obtained in the form of a white powder (m.p.=126° C.). Yield=85%

Workup

  1. customafter crystallization from dichloromethane/heptane, 560 mg of (E)-3-[3′-(1-propyl-3-heptylureido)biphenyl-4-yl]acrylic acid

Sources & evidence

ORD record
ord-0385de6011b64eac97034e2c96f3a946
Source dataset
uspto-grants-2011_01
Patent number
US07863332B2

Reaction notes

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